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ANTISENSE: ISIS, PROMISING RESULTS.
couplesseduceteens x nd13 xDate: 11 Dec 2007 Time: 18:47:58
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Date: 18 Jun 2001
Time: 09:21:25
Comments
In a Phase I/II clinical trial, ISIS 14803 demonstrated dose-dependent antiviral activity, decreasing viral titers, or level of virus in blood, in patients with drug resistant chronic Hepatitis C Virus (HCV) on drug resistant forms. All but one patient had failed previous interferon-based therapy.
ISIS 14803 was well tolerated.
Adverse events reported were minor and non-specific.
ALT flares were not accompanied by changes in bilirubin, albumin, or prothrombin time, which are measures of liver synthetic function.
Liver biopsy results obtained during an ALT flare did not show evidence of drug-related liver toxicity.
Antisense is starting to shpow results.
(Refer to Prohost Newsletter, June 2001.)
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